Consumption by Muscarinic Receptor Stimulation in Rat Parotid and Submandibular Acinar Cells
نویسنده
چکیده
Isoproterenol and cAMP Block ERK Phosphorylation and Enhance [Ca]i Increases and Oxygen Consumption by Muscarinic Receptor Stimulation in Rat Parotid and Submandibular Acinar Cells Stephen P. Soltoff and Lee Hedden From Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115 Running head: Isoproterenol blocks ERK phosphorylation by M3R, P2X7R, and EGFR Address correspondence to: Stephen P. Soltoff, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, EC/CLS-406, Boston, MA 02215. PHONE: 617-735-2640; FAX: 617-735-2646; E-mail: [email protected]
منابع مشابه
Isoproterenol and cAMP Block ERK Phosphorylation and Enhance [Ca]i Increases and Oxygen Consumption by Muscarinic Receptor Stimulation in Rat Parotid and Submandibular Acinar Cells
Isoproterenol and cAMP Block ERK Phosphorylation and Enhance [Ca]i Increases and Oxygen Consumption by Muscarinic Receptor Stimulation in Rat Parotid and Submandibular Acinar Cells Stephen P. Soltoff and Lee Hedden From Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115 Running head: Isoproterenol blocks ERK phosphorylatio...
متن کاملIsoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.
Salivary glands are innervated by sympathetic and parasympathetic neurons, which release neurotransmitters that promote fluid secretion and exocytosis when they bind to muscarinic and beta-adrenergic receptors, respectively. Signaling pathways downstream of these receptors are mainly distinct, but there is cross-talk that affects receptor-dependent events. Here we report that the beta-adrenergi...
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Sympathetic stimulation induces weak salivation compared with parasympathetic stimulation. To clarify this phenomenon in salivary glands, we investigated cAMP-induced modulation of Ca(2+)-activated Cl(-) secretion from rat parotid and submandibular acinar cells because fluid secretion from salivary glands depends on the Cl(-) secretion. Carbachol (Cch), a Ca(2+)-increasing agent, induced hyperp...
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Large volumes of saliva are generated by transepithelial Cl(-) movement during parasympathetic muscarinic receptor stimulation. To gain further insight into a major Cl(-) uptake mechanism involved in this process, we have characterized the anion exchanger (AE) activity in mouse serous parotid and mucous sublingual salivary gland acinar cells. The AE activity in acinar cells was Na(+) independen...
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Muscarinic acetylcholine receptors in isolated rat pancreatic acinar cells have an apparent Mr of 88 000, which could be decreased to 46 000 by papain, as deduced by covalent binding of the specific alkylating agent [3H]propylbenzilylcholine mustard. Muscarinic receptors on papain-treated acinar cells retained the antagonist-binding site and both high- and low-affinity binding sites for the cho...
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